Spring 2018
(1-1:50PM)

   

TOPIC (part 2 of biofundamentals her)
Last updated: 3 March 2018

 

Complete readings (using Nota Bene) BEFORE class
the complete Biofundamentals text is : HERE





 
           
Wednesday
17 January
    1. Introduction to the class - slides  

introduction to NB and beSocratic
Optional reading Mendel, Darwin & Evolution

           
Friday
19 January
   

2. Core ideas in molecular / cell biology
Reviewing important terms & concepts in molecular biology -
slides

 

Read: Ellis-van Creveld syndrome and the Amish
Complete
introductory beSocratic survey
Review
Chapters 7-9 if necessary





 
Monday
22 January
   

3. Where do genes, alleles & mutations come from? - slides

 

Read: Chapter 11 pp. 225-229
Read: Where do all those gene come from?

           
Wednesday
24 January
   

4. How do allelic differences / mutations influence gene function? - slides

 

Read: Chapter 11 pp. 229-231

           
Friday
26 January
   

5. finish molecular biology review - slides

 






 
Monday
29 January
   

6. Reproduction in prokaryotes (conjugation) - slides

 

Read: Chapter 12. pp. 232-234
optional: How afraid of human cloning should we be

           
Wednesday
31 January
   

7. Horizontal gene transfer
(transformation + transduction)
- slides

 

Read: Chapter 12. pp. 235-237
optional : Lateral gene transfer in eukaryotes: tip of the iceberg or of an ice cube?
optional: Researchers Discover 10 New Immune Systems in Bacteria

           
Friday
2 February
   

(I will be away, no class)

 

 





 
Monday
5 February
   

8. Eukaryotic reproduction
- somatic divisions & checkpoints - slides

 
Read: Chapter 13. pp. 238-241
optional: cell cycle regulation by checkpoints
           
Wednesday
7 February
   

9. Sex determination and meiosis introduced - slides

 

Read: Chapter 13. pp. 241- 244
Why Males Are Biology's Riskier Sex

           
Friday
9 February
   

10.Meiosis - slides

 

Read: Chapter 13. pp. 244- 248
The evolution of sex (a video lecture from Yale)





 
Monday
12 February
   

11.recombination slides

 

Read: Chapter 13. pp. 244 - 248

           
Wednesday
14 February
   

12. Linkage and haplotypes - slides

 

Read: Chapter 13. pp. 244 - 248

           
Friday
16 February
   

13. Imprinting slides

 

Read: Chapter 13. pp. 248 - 250
Read Imprinting


   
 
Monday
19 February
   

14.X-inactivation – slides

 

Read: Chapter 13. pp. 250- 252

           
Wednesday
21 February
   

15. in class practice exam

 

practice miderm

           
Friday
23 February
   

16. review for midterm 1

 

review questions you should be able to answer





 
Monday
26 February
   

17. Midterm EXAM 1

 

midterm exam answers

           
Wednesday
28 February
   

19. Discuss term paper / video
presentation topics

 

 

           
Friday
2 March
  `

20. Luria-Delbruck – slides

 

Read: Chapter 14. pp.253-256

 


 
Monday
5 March
   

21. Generating mutations – slides

 

Read: Chapter 14. pp.256-261 | READ CRISPR
optional: war in the womb (material-fetal conflict)

           
Wednesday
7 March
   

22. Making mutations Intelligently:
CRISPR and such - slides

 

Optional reading: The Ames Test and the Real World
READ review on CRISPR
Optional reading: a history of CRISPR-CAS

           
Friday
9 March
   

23. Getting Mendelian - slides

  Read: Chapter 15. pp.262-265




 
Monday
12 March
   

24. Chi square -slides

 

Read: Chapter 15. pp.265-269

           
Wednesday
14 March
   

25.Linkage - slides

 

Read: Chapter 15. pp. 269-271

           
Friday
16 March
   

26. linkage - slides

 

Read: Chapter 15. pp.271-274
optional reading: Gene Interactions & phenotype effects





 
Monday
19 March
   

27. genetic interactions - slides

 

Read: Chapter 15. pp. 274-276
Optional reading: Genetic modifiers and Oligogenic traits

           
Wednesday
21 March
   

28. interactions-evolution (Hardy-Weinberg)

 

Read: Chapter 15. pp.276-278

           
Friday
23 March
   

29. presenting first draft storyboards

 

course section two - topics to review





 
SPRING    
BREAK
 

 

 


 
Monday
2 April
   

30. practice midterm 2

 

practice midterm questions

           
Wednesday
4 April
   

31. midterm review

 

 

           
Friday
6 April
   

32. MIDTERM 2

 

answered midterm





 

Monday
9 April

   

33. Maternal effects and zygotic development - slides

 

Read: Chapter 16. 279-283

           

Wednesday
11 April

   

34. Germ line alleles and human pathologies - slides

 

Read: Chapter 16. pp. 279-283
Optional: Nothing in cancer makes sense except…

           
Friday
13 April
   

35. Mendelian and non-mendelian traits slides

 

Read: Chapter 16. pp. 283-287


   
 
Monday
16 April
   

36. Methods: Where are genes expressedslides

  Optional: Nothing in cancer makes sense except…
           
Wednesday
18 April
   

37. Methods completed
slides

 

Read: Chapter 16. pp. 287-292

         
Sweet Tooth Gene Tied to Less Body Fat
Friday
20 April
   

38. First presentation for videos

 



   
 
Monday
23 April
   

39.complete first presentation for videos

 

 

           
Wednesday
25 April
   

40. GWAS - Dr. Stephanie Moon - slides

 

Read: Chapter 16. pp. 292-293

Couresa video: here and snp tutorial: here
Listen to GWAS overview
optional paper on penetrance/expressivity

           
Friday
27 April
   

41. Should biohacking be legal - slides
(even if it effects future generations)?

 

READ: "I want to help humans genetically modify themselves"
+ Mail-Order CRISPR Kits
+ "The FBI and biohackers: an unusual relationship

optional reading for the curious:
A history of the future





 
Monday
30 April
   

42. course review - third section - slides

 

practice questions : practice exam

practice videos: Mendelian pedigrees (first / second)
non-Mendelian: review

           

Wednesday
2 May

   

43.complete course review - slides

 

optional reading for the curious: Royal Society Primer on Forensic DNA analysis

           
Friday
4 May
    Reading Day
 

all videos due (film study) -optional .

FINAL EXAM ANSWER KEY





 
To be announced
   
FINAL EXAM:
SUNDAY - 6th May 2018

7:30 PM - 10:00 PM
GOLD A120
In MCDB A120
 
dinosaurs
          16 December 2015 4:30 PM - 7:00 PM